The Lack of Association between FCN2 Gene Promoter Region Polymorphisms and Dental Caries in Polish Children

被引：11
|
作者：
Olszowski, T. [1 ]
Milona, M. [1 ]
Janiszewska-Olszowska, J. [2 ]
Safranow, K. [3 ]
Skonieczna-Zydecka, K. [4 ]
Walczak, A. [1 ]
Sikora, M. [3 ,5 ]
Chlubek, D. [3 ]
Madlani, A. [4 ]
Adler, G. [4 ]
机构：
[1] Pomeranian Med Univ, Dept Hyg & Epidemiol, Powst Wlkp 72, PL-70111 Szczecin, Poland
[2] Pomeranian Med Univ, Dept Interdisciplinary Dent, Szczecin, Poland
[3] Pomeranian Med Univ, Dept Biochem & Med Chem, Szczecin, Poland
[4] Pomeranian Med Univ, Dept Gerontobiol, Zolnierska 48, PL-71210 Szczecin, Poland
[5] Hosp Minist Interior, Dept Maxillofacial Surg, Kielce, Poland
来源：
CARIES RESEARCH | 2017年 / 51卷 / 01期
关键词：
Children; Dental caries experience; Ficolin-2; Genetic polymorphism; SERUM FICOLIN-2; FUNCTIONAL POLYMORPHISMS; HAPLOTYPES; INFECTIONS; DISEASES; LEPROSY;
D O I：
10.1159/000455054
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The aim of this study was to examine the association of single -nucleotide polymorphisms (SNPs) in the gene encoding ficolin-2 protein (FCN2 gene) at positions-986 (rs17514136), -602 (rs3124953), and -4 (rs3124952) with dental caries in Polish children. Two hundred and sixty Polish Caucasian children aged 15 years were enrolled in this study: 82 with "higher" caries experience (DMFT >5) and 178 with "lower" caries experience (DMFT In addition, subjects with caries experience (DMFT >= 1) and caries-free subjects (DMFT=0) were compared. FCN2 SNPs were genotyped with PCR-RFLP methods. There were no significant differences in the genotype, allele, or haplotype distributions in 3 analyzed SNPs of the FCN2 gene between children with "higher" and those with "lower" caries experience as well as between children with caries experience and caries-free children. In conclusion, we did not find any association of FCN2 promoter polymorphisms at positions -986, -602, and -4 with dental caries in Polish children. (C) 2017 S. Karger AG, Basel
引用
收藏
页码：79 / 84
页数：6
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