Mdm2 inhibitor nutlin-3a induces p53-dependent apoptosis via transcriptiondependent and -independent pathways and overcomes fludarabine-resistance in CLL

被引:0
|
作者
Andreeff, Michael [1 ]
Konopleva, Marina [1 ]
Samudio, Ismael J. [1 ]
McQueen, Teresa [1 ]
Tsao, Twee [1 ]
Zeng, Zhihong [1 ]
Kojima, Kensuke [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4977
引用
收藏
页数:2
相关论文
共 50 条
  • [31] MDM2 antagonist Nutlin-3a protects wild-type p53 cancer cells from paclitaxel
    SHEN HongChang
    Science Bulletin, 2012, (09) : 1007 - 1012
  • [32] Inhibition of MDM2 via Nutlin-3A: A Potential Therapeutic Approach for Pleural Mesotheliomas with MDM2-Induced Inactivation of Wild-Type P53
    Walter, Robert F. H.
    Werner, Robert
    Wessolly, Michael
    Mairinger, Elena
    Borchert, Sabrina
    Schmeller, Jan
    Kollmeier, Jens
    Mairinger, Thomas
    Hager, Thomas
    Bankfalvi, Agnes
    Christoph, Daniel C.
    Eberhardt, Wilfried E. E.
    Ploenes, Till
    Aigner, Clemens
    Schmid, Kurt W.
    Wohlschlaeger, Jeremias
    Mairinger, Fabian D.
    JOURNAL OF ONCOLOGY, 2018, 2018
  • [33] The histone deacetylase inhibitor trichostatin A induces cell cycle arrest and apoptosis in colorectal cancer cells via p53-dependent and -independent pathways
    Meng, Jin
    Zhang, Hai-Hua
    Zhou, Chun-Xiang
    Li, Chen
    Zhang, Feng
    Mei, Qi-Bing
    ONCOLOGY REPORTS, 2012, 28 (01) : 384 - 388
  • [34] MDM2 antagonist Nutlin-3a protects wild-type p53 cancer cells from paclitaxel
    Shen HongChang
    Dong Wei
    Gao DongWei
    Wang GuangHui
    Ma GuoYuan
    Liu Qi
    Du JiaJun
    CHINESE SCIENCE BULLETIN, 2012, 57 (09): : 1007 - 1012
  • [35] MDM2 antagonist Nutlin-3a protects wild-type p53 cancer cells from paclitaxel
    SHEN HongChangDONG WeiGAO DongWeiWANG GuangHuiMA GuoYuanLIU Qi DU JiaJun Department of Thoracic SurgeryProvincial Hospital Affiliated to Shandong UniversityShandong UniversityJinan China
    Chinese Science Bulletin, 2012, 57 (09) : 1007 - 1012
  • [36] MDM2 antagonist Nutlin-3 suppresses the proliferation and differentiation of human pre-osteoclasts through a p53-dependent pathway
    Zauli, Giorgio
    Rimondi, Erika
    Corallini, Federica
    Fadda, Roberto
    Capitani, Silvano
    Secchiero, Paola
    JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 (10) : 1621 - 1630
  • [37] Experimental cryptorchidism induces testicular germ cell apoptosis by p53-dependent and -independent pathways in mice
    Yin, YZ
    DeWolf, WC
    Morgentaler, A
    BIOLOGY OF REPRODUCTION, 1998, 58 (02) : 492 - 496
  • [38] Small molecule inhibitor of MDM2 induces p53-dependent HMGB1 secretion followed by apoptosis in cancer cells and incomplete senescence in normal fibroblasts
    Scott, Gary K.
    Davalos, Albert
    Orjalo, Arturo
    Puckett, Rachel
    Held, Jason
    Yau, Christina
    Campisi, Judith
    Benz, Christopher C.
    CANCER RESEARCH, 2011, 71
  • [39] A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation
    Jane M Valentine
    Sonia Kumar
    Abdeladim Moumen
    BMC Cancer, 11
  • [40] GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest
    L Meng
    J K Hsu
    R Y L Tsai
    Oncogene, 2011, 30 : 1716 - 1726