Towards an HIV-1 cure: measuring the latent reservoir

被引：160

作者：

Bruner, Katherine M. ^{[1
]}

Hosmane, Nina N. ^{[1
]}

Siliciano, Robert F. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA

来源：

TRENDS IN MICROBIOLOGY | 2015年 / 23卷 / 04期

基金：

美国国家卫生研究院;

关键词：

HIV-1; cure; latency; assays; HUMAN-IMMUNODEFICIENCY-VIRUS; CD4(+) T-CELLS; ANTIRETROVIRAL THERAPY; RALTEGRAVIR INTENSIFICATION; DRUG-RESISTANCE; RESIDUAL HIV-1; PLASMA VIREMIA; QUANTITATIVE ASSAY; INFECTED PATIENTS; VIRAL LOAD;

D O I：

10.1016/j.tim.2015.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The latent reservoir (LR) of HIV-1 in resting memory CD4(+) T cells serves as a major barrier to curing HIV-1 infection. While many PCR- and culture-based assays have been used to measure the size of the LR, correlation between results of different assays is poor and recent studies indicate that no available assay provides an accurate measurement of reservoir size. The discrepancies between assays are a hurdle to clinical trials that aim to measure the efficacy of HIV-1 eradication strategies. Here we describe the advantages and disadvantages of various approaches to measuring the LR.

引用

页码：192 / 203

页数：12

共 50 条

[1] Insights into the HIV-1 Latent Reservoir and Strategies to Cure HIV-1 Infection
Bai, Ruojing
Lv, Shiyun
Wu, Hao
Dai, Lili
[J]. DISEASE MARKERS, 2022, 2022
[2] The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies
Cohn, Lillian B.
Chomont, Nicolas
Deeks, Steven G.
[J]. CELL HOST & MICROBE, 2020, 27 (04) : 519 - 530
[3] Recent developments in the search for a cure for HIV-1 infection: Targeting the latent reservoir for HIV-1
Siliciano, Janet D.
Siliciano, Robert F.
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 134 (01) : 12 - 19
[4] A quantitative approach for measuring the reservoir of latent HIV-1 proviruses
Bruner, Katherine M.
Wang, Zheng
Simonetti, Francesco R.
Bender, Alexandra M.
Kwon, Kyungyoon J.
Sengupta, Srona
Fray, Emily J.
Beg, Subul A.
Antar, Annukka A. R.
Jenike, Katharine M.
Bertagnolli, Lynn N.
Capoferri, Adam A.
Kufera, Joshua T.
Timmons, Andrew
Nobles, Christopher
Gregg, John
Wada, Nikolas
Ho, Ya-Chi
Zhang, Hao
Margolick, Joseph B.
Blankson, Joel N.
Deeks, Steven G.
Bushman, Frederic D.
Siliciano, Janet D.
Laird, Gregory M.
Siliciano, Robert F.
[J]. NATURE, 2019, 566 (7742) : 120 - +
[5] TZA: a novel assay for measuring the latent HIV-1 reservoir
Gupta, Phalguni
Sanyal, Anwesha
Mailliard, Robbie B.
[J]. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2017, 17 (12) : 1033 - 1035
[6] A quantitative approach for measuring the reservoir of latent HIV-1 proviruses
Katherine M. Bruner
Zheng Wang
Francesco R. Simonetti
Alexandra M. Bender
Kyungyoon J. Kwon
Srona Sengupta
Emily J. Fray
Subul A. Beg
Annukka A. R. Antar
Katharine M. Jenike
Lynn N. Bertagnolli
Adam A. Capoferri
Joshua T. Kufera
Andrew Timmons
Christopher Nobles
John Gregg
Nikolas Wada
Ya-Chi Ho
Hao Zhang
Joseph B. Margolick
Joel N. Blankson
Steven G. Deeks
Frederic D. Bushman
Janet D. Siliciano
Gregory M. Laird
Robert F. Siliciano
[J]. Nature, 2019, 566 : 120 - 125
[7] Measuring the size and decay dynamics of the HIV-1 latent reservoir
Liu, Runxia
Catalano, Allison A.
Ho, Ya-Chi
[J]. CELL REPORTS MEDICINE, 2021, 2 (04)
[8] A Review of Current Strategies Towards the Elimination of Latent HIV-1 and Subsequent HIV-1 Cure
Maina, Edward K.
Adan, Asma A.
Mureithi, Haddison
Muriuki, Joseph
Lwembe, Raphael M.
[J]. CURRENT HIV RESEARCH, 2021, 19 (01) : 14 - 26
[9] HIV-1: towards understanding the nature and quantifying the latent reservoir
Chatzidimitriou, D.
Tsotridou, E.
Grigoropoulos, P.
Skoura, L.
[J]. ACTA VIROLOGICA, 2020, 64 (01) : 3 - 9
[10] In Vivo Dynamics of the Latent Reservoir for HIV-1: New Insights and Implications for Cure
Siliciano, Janet D.
Siliciano, Robert F.
[J]. ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2022, 17 : 271 - 294

← 1 2 3 4 5 →