The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies

被引：167

作者：

Cohn, Lillian B. ^{[1
,2
]}

Chomont, Nicolas ^{[3
,4
]}

Deeks, Steven G. ^{[2
]}

机构：

[1] Chan Zuckerberg Biohub, San Francisco, CA USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[3] Univ Montreal, Ctr Rech CHUM, Montreal, PQ, Canada

[4] Univ Montreal, Dept Microbiol Infectiol & Immunol, Montreal, PQ, Canada

来源：

CELL HOST & MICROBE | 2020年 / 27卷 / 04期

基金：

美国国家卫生研究院;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; CD4(+) T-CELLS; ANTIRETROVIRAL THERAPY; IMMUNE ACTIVATION; PROGENITOR CELLS; NATURAL CONTROL; INTACT HIV-1; PERSISTENCE; REPLICATION; PROVIRUSES;

D O I：

10.1016/j.chom.2020.03.014

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the integrated HIV genome persists indefinitely within CD4(+) T cells and perhaps other cells. Here, we describe the mechanisms thought to contribute to its persistence during treatment and highlight findings from numerous recent studies describing the importance of cell proliferation in that process. Continued progress elucidating the biology will enhance our ability to develop effective curative interventions.

引用

页码：519 / 530

页数：12

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