Colorectal cancer stem cell: a potential therapeutic target

被引：7
|
作者：
Tao, Haiying [1 ]
Zhu, Yongliang [1 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 2, Dept Gastroenterol, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China
来源：
CLINICAL & TRANSLATIONAL ONCOLOGY | 2011年 / 13卷 / 12期
关键词：
Colorectal cancer; Stem cell; Marker; Pathway; Targeted intervention; SMALL-INTESTINE; COLON; EXPRESSION; MARKER; DIFFERENTIATION; ANTAGONISTS; HIERARCHY; RENEWAL; GROWTH;
D O I：
10.1007/s12094-011-0743-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The discovery of cancer stem cells has improved our understanding of tumour occurrence and development. Colorectal cancer stem cells may be derived from mutations in normal intestinal epithelial stem cells. CD133(+) and aldehyde dehydrogenase 1 (ALDH1)(+) cells have strong tumorigenic capacities and may represent different subpopulations of colorectal cancer stem cells. Multiple signalling pathways, especially the Wnt pathway, are important in colorectal cancer occurrence and development, and maintaining the stemness of colorectal cancer stem cells. Identifying colorectal cancer stem cells and understanding the related signalling pathways are important for developing new targeted interventions for colorectal cancer.
引用
收藏
页码：833 / 838
页数：6
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