Metal-Free Reductive Amination of Ketones with Amines Using Formic Acid as the Reductant under BF3 . Et2O Catalysis

被引：7
|
作者：
Luo, Zhenli [1 ]
Wan, Shanhong [1 ]
Pan, Yixiao [1 ]
Yao, Zhen [1 ]
Zhang, Xin [1 ]
Li, Bohan [1 ]
Li, Jiajie [1 ]
Xu, Lijin [1 ]
Fan, Qing-Hua [2 ,3 ]
机构：
[1] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China
[2] Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100190, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 11卷 / 03期
基金：
中国国家自然科学基金;
关键词：
amine; BF3; formic acid; ketone; reductive amination; transfer hydrogenation; LEWIS PAIR CHEMISTRY; TRANSFER HYDROGENATION; TERTIARY-AMINES; ALDEHYDES; NANOPARTICLES; SCOPE;
D O I：
10.1002/ajoc.202100707
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
BF3 . Et2O has been found to effectively catalyze reductive amination of ketones with amines employing formic acid as the reductant under metal-free conditions. This transformation tolerates a broad range of primary and secondary amines and differently decorated ketones, delivering N-alkylated amines in good to excellent yields with high compatibility of functional groups. The synthetic potential of this protocol is demonstrated by its application in the preparation of biologically and pharmaceutically relevant compounds.
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页数：7
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