Immunometabolic alterations in lupus: where do they come from and where do we go from there?

被引：9

作者：

Ma, Longhuan ^{[1
]}

Roach, Tracoyia ^{[1
]}

Morel, Laurence ^{[1
]}

机构：

[1] Univ Texas Hlth San Antonio, Dept Microbiol Immunol & Mol Genet, 7703 Floyd Curl Dr,MC7758, San Antonio, TX 78229 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2022年 / 78卷

基金：

美国国家卫生研究院;

关键词：

HELPER T-CELL; METABOLIC-REGULATION; B-CELLS; SUSCEPTIBILITY; ERYTHEMATOSUS; DIFFERENTIATION; AUTOIMMUNITY; ITACONATE; PRONE; MICE;

D O I：

10.1016/j.coi.2022.102245

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Systemic lupus erythematosus (SLE) is an autoimmune disease in which the overactivation of the immune system has been associated with metabolic alterations. Targeting the altered immunometabolism has been proposed to treat SLE patients based on their results obtained and mouse models of the disease. Here, we review the recent literature to discuss the possible origins of the alterations in the metabolism of immune cells in lupus, the dominant role of mitochondrial defects, technological advances that may move the field forward, as well as how targeting lupus immunometabolism may have therapeutic potential.

引用

页数：11

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