Bespoke Turing Systems

被引:38
|
作者
Woolley, Thomas E. [1 ]
Krause, Andrew L. [2 ]
Gaffney, Eamonn A. [2 ]
机构
[1] Cardiff Univ, Cardiff Sch Math, Senghennydd Rd, Cardiff CF24 4AG, Wales
[2] Univ Oxford, Math Inst, Radcliffe Observ Quarter, Andrew Wiles Bldg,Woodstock Rd, Oxford OX2 6GG, England
基金
英国生物技术与生命科学研究理事会;
关键词
Turing patterns; Identifiability; REACTION-DIFFUSION MECHANISMS; PATTERN-FORMATION; MODEL; INSTABILITIES; BIFURCATION; BOUNDARY; DOMAINS; SPOTS;
D O I
10.1007/s11538-021-00870-y
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Reaction-diffusion systems are an intensively studied form of partial differential equation, frequently used to produce spatially heterogeneous patterned states from homogeneous symmetry breaking via the Turing instability. Although there are many prototypical "Turing systems" available, determining their parameters, functional forms, and general appropriateness for a given application is often difficult. Here, we consider the reverse problem. Namely, suppose we know the parameter region associated with the reaction kinetics in which patterning is required-we present a constructive framework for identifying systems that will exhibit the Turing instability within this region, whilst in addition often allowing selection of desired patterning features, such as spots, or stripes. In particular, we show how to build a system of two populations governed by polynomial morphogen kinetics such that the: patterning parameter domain (in any spatial dimension), morphogen phases (in any spatial dimension), and even type of resulting pattern (in up to two spatial dimensions) can all be determined. Finally, by employing spatial and temporal heterogeneity, we demonstrate that mixed mode patterns (spots, stripes, and complex prepatterns) are also possible, allowing one to build arbitrarily complicated patterning landscapes. Such a framework can be employed pedagogically, or in a variety of contemporary applications in designing synthetic chemical and biological patterning systems. We also discuss the implications that this freedom of design has on using reaction-diffusion systems in biological modelling and suggest that stronger constraints are needed when linking theory and experiment, as many simple patterns can be easily generated given freedom to choose reaction kinetics.
引用
收藏
页数:32
相关论文
共 50 条
  • [41] A Turing machine simulation by P systems without charges
    Leporati, Alberto
    Manzoni, Luca
    Mauri, Giancarlo
    Porreca, Antonio E.
    Zandron, Claudio
    JOURNAL OF MEMBRANE COMPUTING, 2020, 2 (02) : 71 - 79
  • [42] Turing instabilities in prey–predator systems with dormancy of predators
    Masataka Kuwamura
    Journal of Mathematical Biology, 2015, 71 : 125 - 149
  • [43] THE BESPOKE SENTENCE
    RAEBURN, W
    BRITISH JOURNAL OF CRIMINOLOGY, 1965, 5 (03): : 266 - 274
  • [44] A Bespoke Elephant
    Hoving, Ab
    Van Der Vliet, Jeroen
    RIJKSMUSEUM BULLETIN, 2012, 60 (02): : 130 - 143
  • [45] Bespoke peptides
    不详
    CHEMICAL & ENGINEERING NEWS, 2007, 85 (14) : 11 - 11
  • [46] Bespoke medicine
    不详
    NEW SCIENTIST, 2004, 183 (2464) : 5 - 5
  • [47] BESPOKE FLIGHT
    JONES, D
    NATURE, 1991, 350 (6316) : 278 - 278
  • [48] Bespoke practice
    Kneebone, Roger L.
    LANCET, 2017, 389 (10064): : 28 - 29
  • [49] Bespoke automation
    不详
    CHEMISTRY & INDUSTRY, 2006, (24) : 39 - 39
  • [50] Bespoke refrigeration
    不详
    CHEMISTRY & INDUSTRY, 2006, (24) : 37 - 37