Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding

被引：38
|
作者：
Khan, Abid
Silversides, Jon D.
Madden, Leigh
Greenman, John
Archibald, Stephen J.
机构：
[1] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England
[2] Univ Hull, Inst Clin Biosci, Kingston Upon Hull HU6 7RX, N Humberside, England
[3] Univ Hull, Med Res Lab, Kingston Upon Hull HU6 7RX, N Humberside, England
来源：
CHEMICAL COMMUNICATIONS | 2007年 / 04期
基金：
英国惠康基金;
关键词：
D O I：
10.1039/b614557d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The copper(II) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.
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页码：416 / 418
页数：3
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