A murine model for the study of Chlamydia trachomatis genital infections during pregnancy

被引：15
|
作者：
Pal, S [1 ]
Peterson, EM [1 ]
de la Maza, LM [1 ]
机构：
[1] Univ Calif Irvine, Dept Pathol, Irvine, CA 92697 USA
来源：
INFECTION AND IMMUNITY | 1999年 / 67卷 / 05期
关键词：
D O I：
10.1128/IAI.67.5.2607-2610.1999
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Pregnant BALB/c mice were inoculated intravaginally on day 5 of gestation with the Chlamydia trachomatis mouse pneumonitis biovar. Animals that received 10(5), 10(6), or 10(7) inclusion-forming units (IFU) of C. trachomatis delivered prematurely on days 15 to 16 of gestation. A focal inflammatory infiltrate was observed in the wall of the uterus on the day 14 of gestation in animals inoculated with 105 IFU. In this group of mice, immunohistochemical analysis showed chlamydial inclusions in the endometrium and fetal membranes.
引用
收藏
页码：2607 / 2610
页数：4
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