Electrochemical Studies of the Interaction of Quercetin with DNA

The interaction of DNA with quercetin was studied using scanning electrochemical microscopy and electrochemical impedance spectroscopy at glass carbon electrode. Information such as the surface coverage of the film and apparent rate constant of the redox active probe in solution was obtained. It is deduced that quercetin interacting with DNA forms a kind of electrochemical inactive supramolecular complex. It has been pointed out that the electron transfer on the electrode surface was hindered therefore the normalized current decreased. The estimation of the electrode coverage and hindrance provided further evidences for information of the interaction of quercetin with DNA. The kinetics constant was obtained from electrochemical impedance spectroscopy.