Molecular epidemiology of KPC-2-producing Klebsiella pneumoniae isolates in Brazil: the predominance of sequence type 437

被引：65
|
作者：
Seki, Liliane M. [1 ]
Pereira, Polyana S. [1 ]
de Souza, Maria da Penha A. H. [2 ]
Conceicao, Magda de S. [3 ]
Marques, Elizabeth A. [4 ]
Porto, Carlos Oliveira [5 ]
Colnago, Elvira Maria L. [6 ]
Alves, Carlene de F. M. [7 ]
Gomes, Deize [8 ]
Carvalho Assef, Ana Paula D. A. [1 ]
Samuelsen, Orjan [9 ]
Asensi, Marise D. [1 ]
机构：
[1] Fiocruz MS, Inst Oswaldo Cruz, Lab Pesquisa Infeccao Hosp, BR-21045900 Rio De Janeiro, Brazil
[2] Lab Cent Saude Publ Espirito Santo, BR-29052121 Vitoria, Espirito Santo, Brazil
[3] Hosp Geral Bonsucesso, BR-21041030 Rio De Janeiro, Brazil
[4] Hosp Univ Pedro Ernesto UERJ, BR-20551030 Rio De Janeiro, Brazil
[5] Lab Cent Saude Publ Goias, BR-74853120 Gioania Goias, Brazil
[6] Lab Cent Saude Publ Rio de Janeiro, BR-20231092 Rio De Janeiro, Brazil
[7] Lab Cent Saude Publ Minas Gerais, BR-30510010 Belo Horizonte, MG, Brazil
[8] Lab Cent Saude Publ Pernambuco, BR-50050210 Recife, PE, Brazil
[9] Univ Hosp N Norway, Dept Microbiol & Infect Control, Reference Ctr Detect Antimicrobial Resistance, N-9038 Tromso, Norway
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2011年 / 70卷 / 02期
关键词：
K; pneumoniae; KPC-2; PFGE; MLST; Brazil; HYDROLYZING BETA-LACTAMASE; CARBAPENEMASE; EMERGENCE; KPC-2; DISSEMINATION;
D O I：
10.1016/j.diagmicrobio.2011.01.006
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The aim of this study was to investigate the genetic relatedness of 57 KPC-2-producing Klebsiella pneumoniae isolates from 5 states in Brazil, during 2006-2009. Pulse-field gel electrophoresis analysis identified 10 pulsotypes. The pulsotype designated as Kp-RJ (Klebsiella pneumoniae Rio de Janeiro) was the dominant clone found in the states of Rio de Janeiro and Espirito Santo. Multilocus sequence typing of Kp-RJ assigned it to ST 437. Sequence types ST11, ST16, ST25, ST70, ST101, ST105, ST423, ST442, and ST443 were also identified. These results indicate the dissemination of a successful KPC-producing clone (ST437) in Brazil, which is a single locus variant of ST258. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：274 / 277
页数：4
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