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Molecular epidemiology of KPC-2-producing Klebsiella pneumoniae isolates in Brazil: the predominance of sequence type 437
被引:65
|作者:
Seki, Liliane M.
[1
]
Pereira, Polyana S.
[1
]
de Souza, Maria da Penha A. H.
[2
]
Conceicao, Magda de S.
[3
]
Marques, Elizabeth A.
[4
]
Porto, Carlos Oliveira
[5
]
Colnago, Elvira Maria L.
[6
]
Alves, Carlene de F. M.
[7
]
Gomes, Deize
[8
]
Carvalho Assef, Ana Paula D. A.
[1
]
Samuelsen, Orjan
[9
]
Asensi, Marise D.
[1
]
机构:
[1] Fiocruz MS, Inst Oswaldo Cruz, Lab Pesquisa Infeccao Hosp, BR-21045900 Rio De Janeiro, Brazil
[2] Lab Cent Saude Publ Espirito Santo, BR-29052121 Vitoria, Espirito Santo, Brazil
[3] Hosp Geral Bonsucesso, BR-21041030 Rio De Janeiro, Brazil
[4] Hosp Univ Pedro Ernesto UERJ, BR-20551030 Rio De Janeiro, Brazil
[5] Lab Cent Saude Publ Goias, BR-74853120 Gioania Goias, Brazil
[6] Lab Cent Saude Publ Rio de Janeiro, BR-20231092 Rio De Janeiro, Brazil
[7] Lab Cent Saude Publ Minas Gerais, BR-30510010 Belo Horizonte, MG, Brazil
[8] Lab Cent Saude Publ Pernambuco, BR-50050210 Recife, PE, Brazil
[9] Univ Hosp N Norway, Dept Microbiol & Infect Control, Reference Ctr Detect Antimicrobial Resistance, N-9038 Tromso, Norway
关键词:
K;
pneumoniae;
KPC-2;
PFGE;
MLST;
Brazil;
HYDROLYZING BETA-LACTAMASE;
CARBAPENEMASE;
EMERGENCE;
KPC-2;
DISSEMINATION;
D O I:
10.1016/j.diagmicrobio.2011.01.006
中图分类号:
R51 [传染病];
学科分类号:
100401 ;
摘要:
The aim of this study was to investigate the genetic relatedness of 57 KPC-2-producing Klebsiella pneumoniae isolates from 5 states in Brazil, during 2006-2009. Pulse-field gel electrophoresis analysis identified 10 pulsotypes. The pulsotype designated as Kp-RJ (Klebsiella pneumoniae Rio de Janeiro) was the dominant clone found in the states of Rio de Janeiro and Espirito Santo. Multilocus sequence typing of Kp-RJ assigned it to ST 437. Sequence types ST11, ST16, ST25, ST70, ST101, ST105, ST423, ST442, and ST443 were also identified. These results indicate the dissemination of a successful KPC-producing clone (ST437) in Brazil, which is a single locus variant of ST258. (C) 2011 Elsevier Inc. All rights reserved.
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页码:274 / 277
页数:4
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