One-Pot Synthesis of Pyrrolo[1,2-a]quinoxaline Derivatives via a Copper-Catalyzed Aerobic Oxidative Domino Reaction

被引：51
|
作者：
Liu, Huanhuan [1 ]
Duan, Tiantian [1 ]
Zhang, Zeyuan [1 ]
Xie, Caixia [1 ]
Me, Chen [1 ,2 ]
机构：
[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China
[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 12期
基金：
美国国家科学基金会;
关键词：
VITRO ANTIMALARIAL ACTIVITY; BIOLOGICAL EVALUATION; POTENTIAL INHIBITORS; COUPLING REACTION; PART II; KINASE; ROUTE;
D O I：
10.1021/acs.orglett.5b01167
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed process for the synthesis of pyrrolo[1,2-a]quinoxalines from readily available alpha-amino acids and 1-(2-halophenyl)-1H-pyrroles is described. Different functional groups were well tolerated to give the corresponding products.
引用
收藏
页码：2932 / 2935
页数：4
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