Acetic Acid Catalysed One-Pot Synthesis of Pyrrolo[1,2-a]quinoxaline Derivatives

被引：17
|
作者：
Allan, Pia N. M. [1 ]
Ostrowska, Martyna, I [1 ]
Patel, Bhaven [1 ]
机构：
[1] London Metropolitan Univ, Sch Human Sci, 166-220 Holloway Rd, London N7 8DB, England
来源：
SYNLETT | 2019年 / 30卷 / 19期
关键词：
pyrrolo[1,2-a]quinoxaline; catalysis; Pictet-Spengler reaction; 1-(2-aminophenyl)pyrroles; biological heterocycles; BIOLOGICAL EVALUATION; ANTIPROLIFERATIVE ACTIVITY; ANTIMALARIAL ACTIVITY; POTENTIAL INHIBITORS; EFFICIENT SYNTHESIS; HIGH-AFFINITY; DESIGN; QUINOXALINES; ACTIVATION;
D O I：
10.1055/s-0039-1690724
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient acetic acid catalysed reaction has been developed for the synthesis of 4-aryl substituted pyrrolo[1,2-a]quinoxalines from readily available starting materials. A range of structures have been synthesised in very good to excellent yields. The one-pot reaction proceeds through imine formation, cyclisation followed by air oxidation.
引用
收藏
页码：2148 / 2152
页数：5
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