Expression of mRNA of chemokine receptor CXCR4 in feline mammary adenocarcinoma

被引：0

作者：

Tanabe, S

Nakadai, T

Furuoka, H

Oomachi, T

Kobayashi, Y

Omata, Y

Koyama, T

Hondo, E

Uzuka, Y

Sarashina, T

Ducusin, RJT

Shida, T

Dorf, ME

机构：

[1] Obihiro Univ Agr & Vet Med, Lab Vet Internal Med, Dept Vet Med, Obihiro, Hokkaido 0808555, Japan

[2] Obihiro Univ Agr & Vet Med, Vet Physiol Lab, Dept Vet Med, Obihiro, Hokkaido 0808555, Japan

[3] Obihiro Univ Agr & Vet Med, Lab Vet Pathol, Dept Vet Med, Obihiro, Hokkaido 0808555, Japan

[4] Patholab, Kanagawa 2280821, Japan

[5] Azabu Univ, Dept Vet Radiol, Sagamihara, Kanagawa 2298501, Japan

[6] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[7] Obihiro Univ Agr & Vet Med, Lab Vet Anat, Dept Vet Med, Obihiro, Hokkaido 0808555, Japan

来源：

VETERINARY RECORD | 2002年 / 151卷 / 24期

关键词：

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The expression of mRNA of the chemokine receptor CXCR4 in 65 surgically resected mammary adenocarcinomas from cats was investigated by in situ hybridisation. No expression of the receptor's mRNA was detectable in the mammary tissue of healthy cats, but it was expressed in areas adjacent to necrosis, surrounding blood vessels and cells infiltrating the lymphatics of 47 (72.3 per cent) of the 65 samples. There was a significant relationship between lymphatic infiltration by neoplastic cells and the expression of the receptor's mRNA (P<0.005), but there was no significant relationship between its expression and the one-year survival of the cats.

引用

页码：729 / 733

页数：5

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