Discovery of NVP-CGM097, a highly potent and optimized small molecule inhibitor of Mdm2 under evaluation in a Phase I clinical trial

被引：0

作者：

Jeay, Sebastien ^{[1
]}

Berghausen, Joerg ^{[1
]}

Buschmann, Nicole ^{[1
]}

Chene, Patrick ^{[1
]}

Cozens, Robert ^{[1
]}

Erdmann, Dirk ^{[1
]}

Ferretti, Stephane ^{[1
]}

Furet, Pascal ^{[1
]}

Gabriel, Tobias ^{[1
]}

Gessier, Francois ^{[1
]}

Graus-Porta, Diana ^{[1
]}

Hofmann, Francesco ^{[1
]}

Holzer, Philipp ^{[1
]}

Ito, Moriko ^{[1
]}

Jacoby, Edgar ^{[1
]}

Jensen, Michael ^{[1
]}

Kallen, Joerg ^{[1
]}

Lang, Marc ^{[1
]}

Lisztwan, Joanna ^{[1
]}

Murakami, Masato ^{[1
]}

Pissot-Soldermann, Carole ^{[1
]}

Ruetz, Stephan ^{[1
]}

Rynn, Caroline ^{[1
]}

Sterker, Dario ^{[1
]}

Stutz, Stefan ^{[1
]}

Valat, Therese ^{[1
]}

Wiesmann, Marion ^{[1
]}

Masuya, Keiichi ^{[1
]}

机构：

[1] Novartis Inst Biomed Res, Basel, Switzerland

来源：

CANCER RESEARCH | 2014年 / 74卷 / 19期

关键词：

D O I：

10.1158/1538-7445.AM2014-1797

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

1797

引用

页数：2

共 15 条

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[2] The Mdm2 inhibitor, NVP-CGM097, in combination with the BRAF inhibitor NVP-LGX818 elicits synergistic antitumor effects in melanoma
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[4] The MDM2 Inhibitor NVP-CGM097 Is Highly Active in a Randomized Preclinical Trial of B-Cell Acute Lymphoblastic Leukemia Patient Derived Xenografts
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[6] NVP-CGM097: a novel p53-Mdm2 inhibitor exhibiting potent antitumor activity in mouse models of human cancer
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[9] Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia
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