IAPP boosts islet macrophage IL-1 in type 2 diabetes

被引：30
|
作者：
Mandrup-Poulsen, Thomas [1 ,2 ,3 ]
机构：
[1] Univ Copenhagen, Dept Biomed Sci, Copenhagen, Denmark
[2] Hagedorn Res Inst, Gentofte, Denmark
[3] Karolinska Inst, Dept Med & Surg, Stockholm, Sweden
来源：
NATURE IMMUNOLOGY | 2010年 / 11卷 / 10期
关键词：
OXIDATIVE STRESS; INTERLEUKIN-1; ACTIVATION; MELLITUS; PROTEIN;
D O I：
10.1038/ni1010-881
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IAPP, a hormone secreted together with insulin and deposited in pancreatic islets in type 2 diabetes, can induce macrophage processing of interleukin 1 linked to beta-cell destruction in type 2 diabetes.
引用
收藏
页码：881 / 883
页数：4
相关论文
共 50 条
  • [21] Effects of IL-1 on the revascularization of islet grafts
    Castaner, O.
    Tellez, N.
    Estilles, E.
    Joanny, G.
    Escoriza, J.
    Montanya, E.
    DIABETOLOGIA, 2008, 51 : S242 - S243
  • [22] The Impact of IL-1 in Islet Antiviral Responses
    Bartosiak, Jacob
    Corbett, John A.
    DIABETES, 2024, 73
  • [23] IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes
    Berchtold, Lukas A.
    Larsen, Claus M.
    Vaag, Allan
    Faulenbach, Mirjam
    Workman, Christopher T.
    Kruhoffer, Mogens
    Donath, Marc
    Mandrup-Poulsen, Thomas
    EUROPEAN CYTOKINE NETWORK, 2009, 20 (02) : 81 - 87
  • [24] The Impact of Pharmacotherapy of Type 2 Diabetes Mellitus on IL-1β, IL-6 and IL-10 Secretion
    Borowska, Magdalena
    Dworacka, Marzena
    Wesolowska, Anna
    Winiarska, Hanna
    Krzyzagorska, Ewa
    Dworacki, Grzegorz
    PHARMACOLOGY, 2016, 97 (3-4) : 189 - 194
  • [25] Serum IL-1, IL-2, TNFα and INFγ levels of patients with type 1 diabetes mellitus and their siblings
    Özer, G
    Teker, Z
    Çetiner, S
    Yilmaz, M
    Topaloglu, AK
    Önenli-Mungan, N
    Yüksel, B
    JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2003, 16 (02): : 203 - 210
  • [26] Islet cell function in type 1 and type 2 diabetes
    Hao, W
    Palmer, JP
    JOURNAL OF CLINICAL LIGAND ASSAY, 1998, 21 (03): : 309 - 317
  • [27] Interleukin (IL)-1α and IL-1β released from islet resident macrophages impair the success of islet transplantation
    Wrublewsky, S.
    Pohlemann, F.
    Roma, L. Prates
    Rother, S.
    Menger, M.
    Laschke, M.
    Ampofo, E.
    DIABETOLOGIA, 2023, 66 (SUPPL 1) : S229 - S229
  • [28] Administration of an IL-1 trap counteracts type 1 diabetes in NOD mice
    Rydgren, T.
    Borjesson, A.
    Sandler, S.
    DIABETOLOGIA, 2010, 53 : S176 - S176
  • [29] Different Retinal Expression Patterns of IL-1α, IL-1β, and Their Receptors in a Rat Model of Type 1 STZ-Induced Diabetes
    Scuderi, Soraya
    D'amico, Agata Grazia
    Federico, Concetta
    Saccone, Salvatore
    Magro, Gaetano
    Bucolo, Claudio
    Drago, Filippo
    D'Agata, Velia
    JOURNAL OF MOLECULAR NEUROSCIENCE, 2015, 56 (02) : 431 - 439
  • [30] Emerging insights into the role of IL-1 inhibitors and colchicine for inflammation control in type 2 diabetes
    Guan, Jianbin
    Abudouaini, Haimiti
    Lin, Kaiyuan
    Yang, Kaitan
    DIABETOLOGY & METABOLIC SYNDROME, 2024, 16 (01):
12345