Treatment of auditory verbal hallucinations with transcranial magnetic stimulation in a patient with psychotic major depression: One-year follow-up

被引：3
|
作者：
Freitas, Catarina [1 ]
Pearlman, Chester [1 ]
Pascual-Leone, Alvaro [1 ,2 ]
机构：
[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Berenson Allen Ctr Noninvas Brain Stimulat, Div Cognit Neurol,Dept Neurol,Med Sch, Boston, MA 02215 USA
[2] Univ Autonoma Barcelona, Inst Univ Neurorehab Guttmann, Badalona, Spain
来源：
NEUROCASE | 2012年 / 18卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Transcranial magnetic stimulation; Auditory verbal hallucinations; Psychotic depressive disorder; Treatment; One-year follow-up; DORSOLATERAL PREFRONTAL CORTEX; LEFT TEMPOROPARIETAL CORTEX; CORTICAL EXCITABILITY; DOPAMINE RELEASE; RTMS TREATMENT; EFFICACY; PREVALENCE; SEVERITY; PATHWAYS; LANGUAGE;
D O I：
10.1080/13554794.2010.547864
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Auditory verbal hallucinations (AVH) in patients with schizophrenia can respond to repetitive transcranial magnetic stimulation (TMS). We report the therapeutic utility of rTMS in a 48-year-old patient with a 20-year history of severe depression (five suicidal gestures and previous failure of ECT) and internal AVH. First, 20 Hz rTMS to the left prefrontal cortex for 3 weeks significantly improved depression (BDI-II: 89% change, lasting 14 months along with weekly/ bi-weekly maintenance treatments), but AVH remained unchanged. The patient also underwent a further course of the left temporo-parietal 1 Hz rTMS and amelioration of AVH severity was achieved (PSYRATS-AH: 53% change) and maintained at 1-year follow-up. AVH respond to rTMS in disorders other than schizophrenia. Furthermore, targeted rTMS to different brain regions can address diverse symptoms in neuropsychiatric conditions.
引用
收藏
页码：57 / 65
页数：9
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