HB S [β6(A3)GLU→VAL, GAG>GTG] AND β-GLOBIN GENE CLUSTER HAPLOTYPE DISTRIBUTION IN MAURITANIA

被引：9
|
作者：
Veten, Fatimetou M. [1 ]
Abdelhamid, Isselmou O. [2 ]
Meiloud, Ghlana M. [1 ]
Ghaber, Sidi M. [2 ]
Salem, Mohamed L. [2 ]
Abbes, Salem [3 ]
Houmeida, Ahmed O. [1 ]
机构：
[1] Fac Sci & Tech, Dept Biol, Nouakchott, Mauritania
[2] Ctr Hosp Natl, Dept Biochim & Hematol, Nouakchott, Mauritania
[3] Inst Pasteur Tunis, Lab Hematol Mol & Cellulaire, Tunis, Tunisia
来源：
HEMOGLOBIN | 2012年 / 36卷 / 04期
关键词：
Hemoglobin (Hb); Hb S; Population; beta(S) Haplotypes; Frequency; Mauritania; HEMOGLOBINOPATHIES; EPIDEMIOLOGY; POPULATION; ORIGIN;
D O I：
10.3109/03630269.2012.688782
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Of 1050 Mauritanian blood donors screened from the two main racial groups, i.e., the Moors and Black Africans, 60 were found to carry Hb S [beta 6(A3) Glu -> Val, GAG>GTG], giving a global frequency of 5.71%. The prevalence observed in the Black African Mauritanians (10.69%) is almost five times that found in the Moor group (2.25%). Four of the five main beta(S) haplotypes were detected in this study: Senegal (77.8%), Benin (8.8%), Arab-Indian (5.5%) and Bantu (4.4%). These data showed that Hb S is a serious public health problem in Mauritania. They also confirm the ethnic heterogeneity of the Mauritanian population.
引用
收藏
页码：311 / 315
页数：5
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