Maternal circulating levels of irisin in intrahepatic cholestasis of pregnancy

被引:10
|
作者
Kirbas, Ayse [1 ]
Daglar, Korkut [1 ]
Timur, Hakan [1 ]
Biberoglu, Ebru [1 ]
Inal, Hasan Ali [2 ]
Kara, Ozgur [1 ]
Yilmaz, Zehra [1 ]
Turkmen, Gulenay [1 ]
Danisman, Nuri [1 ]
机构
[1] Zekai Tahir Burak Womens Hlth Educ & Res Hosp, Dept Perinatol, Ankara, Turkey
[2] Konya Educ & Res Hosp, Dept Obstet & Gynecol, Konya, Turkey
来源
关键词
Bile acid; FXR receptor; insulin resistance; metabolic syndrome; TGR5; BILE-ACID LEVELS; INSULIN SENSITIVITY; GLUCOSE; RESISTANCE; WOMEN; RISK;
D O I
10.3109/14767058.2015.1132694
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: Intrahepatic cholestasis of pregnancy (ICP), the most common liver disease in pregnancy, is characterized by elevated serum total bile acid levels and pruritus. It has become clear that bile acids are no longer labeled as simple detergent-like molecules, but also represent complex hormonal metabolic regulators. ICP has also been associated with increased incidence rates of gestational diabetes mellitus. Irisin is a newly discovered myokine that is able to regulate glucose and lipid levels, thus improving insulin sensitivity. In this study, maternal serum irisin levels were analyzed in order to provide a new perspective on the pathogenesis of ICP.Materials and methods: In this controlled cross-sectional study, 58 consecutive pregnant women with ICP (30 with mild and 28 with severe disease) and 30 healthy women with uncomplicated pregnancies (as the control group) were examined. The maternal irisin, fasting blood glucose, fasting insulin and homeostatic model assessment of insulin resistance levels of the two groups were compared.Results: Serum irisin levels were significantly higher in the severe ICP group than in the mild ICP and control groups (p=0.005 and p<0.001, respectively). At the best cut-off level of 908.875pg/ml, irisin accurately predicted ICP [AUC=0.827 (95% CI: 0.745-0.909; p<0.001)] with sensitivity and specificity rates of 72.5 and 86.8%, respectively. There was a significant negative correlation between irisin and fasting blood glucose levels (r=-0.399; p=0.021).Conclusion: The results of this study indicate that serum irisin levels were significantly higher in women with ICP compared to healthy pregnant controls. However, it is difficult to infer whether high irisin level is a cause or effect of ICP.
引用
收藏
页码:3483 / 3487
页数:5
相关论文
共 50 条
  • [21] Intrahepatic cholestasis of pregnancy. Maternal and fetal implications.
    Gonzalez, A
    Mino, M
    Fontes, J
    Suarez, JF
    Pinel, LM
    Espinosa, MD
    Miranda, JA
    MartinVivaldi, R
    REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS, 1996, 88 (11) : 780 - 784
  • [22] Intrahepatic cholestasis of pregnancy
    Sentilhes, L.
    Bacq, Y.
    JOURNAL DE GYNECOLOGIE OBSTETRIQUE ET BIOLOGIE DE LA REPRODUCTION, 2008, 37 (02): : 118 - 126
  • [23] Intrahepatic Cholestasis of Pregnancy
    Yilmaz, Saynur
    Ustun, Yaprak
    Hizli, Deniz
    Deveer, Ruya
    GAZI MEDICAL JOURNAL, 2012, 23 (04): : 138 - 144
  • [24] Intrahepatic cholestasis of pregnancy
    Geenes, Victoria
    Williamson, Catherine
    WORLD JOURNAL OF GASTROENTEROLOGY, 2009, 15 (17) : 2049 - 2066
  • [25] Intrahepatic cholestasis of pregnancy
    Victoria Geenes
    Catherine Williamson
    World Journal of Gastroenterology, 2009, 15 (17) : 2049 - 2066
  • [26] Intrahepatic Cholestasis of Pregnancy
    Jurk, Stanislaw M.
    Kremer, Andreas E.
    Schleussner, Ekkehard
    GEBURTSHILFE UND FRAUENHEILKUNDE, 2021, 81 (08) : 940 - 947
  • [27] Intrahepatic Cholestasis of Pregnancy
    Williamson, Catherine
    Geenes, Victoria
    OBSTETRICS AND GYNECOLOGY, 2014, 124 (01): : 120 - 133
  • [28] INTRAHEPATIC CHOLESTASIS OF PREGNANCY
    FAGAN, EA
    BRITISH MEDICAL JOURNAL, 1994, 309 (6964): : 1243 - 1244
  • [29] INTRAHEPATIC CHOLESTASIS OF PREGNANCY
    SCHEUER, P
    CHAMBERS, J
    ROGERS, A
    BRITISH MEDICAL JOURNAL, 1995, 310 (6974): : 260 - 260
  • [30] Intrahepatic cholestasis of pregnancy
    Bacq, Y
    Sapey, T
    GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE, 1998, 22 (8-9): : 705 - 713