Amyotrophic lateral sclerosis patients and ocular ptosis

被引：15
|
作者：
Pinto, Susana [2 ]
de Carvalho, Marnede [1 ,2 ]
机构：
[1] Hosp Santa Maria, Dept Neurol, Av Prof Egas Moniz, P-1649028 Lisbon, Portugal
[2] Univ Lisbon, Fac Med, Inst Mol Med, Neuromuscular Unit, Lisbon, Portugal
来源：
CLINICAL NEUROLOGY AND NEUROSURGERY | 2008年 / 110卷 / 02期
关键词：
amyotrophic lateral sclerosis; bulbar-onset; jitter; myasthenia gravis; ptosis;
D O I：
10.1016/j.clineuro.2007.08.022
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Ptosis is not a feature observed in amyotrophic lateral sclerosis (ALS). We describe two old women with bulbar-onset ALS and rapid progression, in whom ptosis and diplopia were noted. They did not improve on pyridostigmine or steroids. Antibodies against acetylcholine receptor were negative, thymoma was excluded, but neurophysiological showed marked neuromuscular transmission failure in orbicularis oculi. We discuss the association between ALS and ocular myasthenia gravis in these cases. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：168 / 170
页数：3
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