Estradiol-dependent effect of nitric oxide on meiotic maturation of mouse oocytes

被引:3
|
作者
Voznesenskaya, TY [1 ]
Blashkiv, TV [1 ]
机构
[1] Ukrainian Acad Sci, Dept Immunol & Cytotox Sera, AA Bogomolets Inst Physiol, Kiev, Ukraine
关键词
NO; estradiol; mouse oocytes;
D O I
10.1007/s10517-005-0494-9
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Estradiol dipropionate decreased the number of oocytes in mouse ovary and suppressed meiotic maturation of these cells. Administration of NO donors sodium nitroprusside and S-nitroso-N-acetylpenicillamine increased the ability of ovarian oocytes to complete meiotic maturation and counteracted the effect of estradiol dipropionate. Our results suggest that estradiol is involved in the regulation of production and release of ovarian NO.
引用
收藏
页码:378 / 380
页数:3
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