Lrig1: a new master regulator of epithelial stem cells

被引：14

作者：

Ordonez-Moran, Paloma

Huelsken, Joerg ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, ISREC Swiss Inst Expt Canc Res, Lausanne, Switzerland

来源：

EMBO JOURNAL | 2012年 / 31卷 / 09期

关键词：

D O I：

10.1038/emboj.2012.73

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The intestine represents the most vigorously renewing, adult epithelial tissue that makes maintenance of its homeostasis a delicate balance between proliferation, cell cycle arrest, migration, differentiation, and cell death. These processes are precisely controlled by a network of developmental signalling cascades, which include Wnt, Notch, BMP/TGF beta, and Hedgehog pathways. A new, elegant study by Wong et al (2012) now adds Lrig1 as a key player in the control of intestinal homeostasis. As for epidermal stem cells, Lrig1 limits the size of the intestinal progenitor compartment by dampening EGF/ErbB-triggered stem cell expansion.

引用

页码：2064 / 2066

页数：3

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