Lrig1: a new master regulator of epithelial stem cells

被引：14
|
作者：
Ordonez-Moran, Paloma
Huelsken, Joerg [1 ]
机构：
[1] Ecole Polytech Fed Lausanne, ISREC Swiss Inst Expt Canc Res, Lausanne, Switzerland
来源：
EMBO JOURNAL | 2012年 / 31卷 / 09期
关键词：
D O I：
10.1038/emboj.2012.73
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The intestine represents the most vigorously renewing, adult epithelial tissue that makes maintenance of its homeostasis a delicate balance between proliferation, cell cycle arrest, migration, differentiation, and cell death. These processes are precisely controlled by a network of developmental signalling cascades, which include Wnt, Notch, BMP/TGF beta, and Hedgehog pathways. A new, elegant study by Wong et al (2012) now adds Lrig1 as a key player in the control of intestinal homeostasis. As for epidermal stem cells, Lrig1 limits the size of the intestinal progenitor compartment by dampening EGF/ErbB-triggered stem cell expansion.
引用
收藏
页码：2064 / 2066
页数：3
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