Ligand-free copper-catalyzed C-S coupling of aryl iodides and thiols

被引：247
|
作者：
Sperotto, Elena [1 ]
van Klink, Gerard P. M. [2 ]
de Vries, Johannes G. [2 ]
van Koten, Gerard [1 ]
机构：
[1] Univ Utrecht, Debye Inst Nanomat Sci, Fac Sci, NL-3584 CH Utrecht, Netherlands
[2] DSM Pharmaceut Prod Adv Synth Catalysis & Dev, NL-6160 MD Geleen, Netherlands
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 14期
关键词：
D O I：
10.1021/jo800491k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A protocol for the copper-catalyzed aryl-sulfur bond formation between aryl iodides and thiophenols is reported. The reaction is catalyzed by a low amount (1-2.5 mol %) of readily available and ligand-free copper iodide salt. A variety of diaryl thioethers are synthesized under relatively mild reaction conditions with good chemoselectivity and functional group tolerance.
引用
收藏
页码：5625 / 5628
页数：4
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