Nurse practitioners play a vital role in the screening and management of alcohol use disorders in primary care. Despite the prevalence and health impact of alcohol misuse, and recommendations for use of regular screening, many providers report lack of preparation and confidence in the identification, treatment, and referral. Several validated and evidence-based screening, assessment, intervention, and treatment options are available, including the Alcohol Use Disorders Identification Test, Alcohol Use Disorders Identification Test-Consumption, and the single-question screen. Similar to screening for other adverse health behaviors, screening and brief intervention for alcohol misuse is a preventive service that nurse practitioners can provide to their patients.