Multiple Approaches to Investigate the Transport and Activity-Dependent Release of BDNF and Their Application in Neurogenetic Disorders

被引：15
|
作者：
Hartmann, David [1 ]
Drummond, Jana [1 ]
Handberg, Erik [1 ]
Ewell, Sharday [1 ]
Pozzo-Miller, Lucas [1 ]
机构：
[1] Univ Alabama Birmingham, Dept Neurobiol, Civitan Int Res Ctr, Birmingham, AL 35294 USA
来源：
NEURAL PLASTICITY | 2012年 / 2012卷
关键词：
FRAGILE-X-SYNDROME; NEUROTROPHIC FACTOR EXPRESSION; RESCUES SYNAPTIC PLASTICITY; GREEN FLUORESCENT PROTEINS; LONG-TERM POTENTIATION; KNOCKOUT MICE EXHIBIT; HUNTINGTONS-DISEASE; RETT-SYNDROME; MOUSE MODEL; VAL66MET POLYMORPHISM;
D O I：
10.1155/2012/203734
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Studies utilizing genetic and pharmacological manipulations in rodent models and neuronal cultures have revealed myriad roles of brain-derived neurotrophic factor (BDNF). Currently, this knowledge of BDNF function is being translated into improvement strategies for several debilitating neurological disorders in which BDNF abnormalities play a prominent role. Common among the BDNF-related disorders are irregular trafficking and release of mature BDNF (mBDNF) and/or its prodomain predecessor, proBDNF. Thus, investigating the conditions required for proper trafficking and release of BDNF is an essential step toward understanding and potentially improving these neurological disorders. This paper will provide examples of disorders related to BDNF release and serve as a review of the techniques being used to study the trafficking and release of BDNF.
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页数：11
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