Dendritic Cell Vaccination for Glioblastoma Multiforme: Clinical Experience and Future Directions

被引：0

作者：

Dejaegher, Joost ^{[1
,2
]}

Solie, Lien ^{[3
]}

De Vleeschouwer, Steven ^{[1
,2
]}

Van Gool, Stefaan W. ^{[2
,3
]}

机构：

[1] Katholieke Univ Leuven, Dept Neurosci, Lab Expt Neurosurg & Neuroanat, Leuven, Belgium

[2] Univ Hosp Leuven, Leuven, Belgium

[3] Katholieke Univ Leuven, Dept Microbiol & Immunol, Pediat Oncol, Leuven, Belgium

来源：

2014 6TH INTERNATIONAL ADVANCED RESEARCH WORKSHOP ON IN SILICO ONCOLOGY AND CANCER INVESTIGATION (IARWISOCI) | 2014年

关键词：

REGULATORY T-CELLS; RECURRENT MALIGNANT GLIOMA; TUMOR VACCINATION; EXOGENOUS ANTIGEN; IMMUNE DEFECTS; IMMUNOTHERAPY; RESPONSES; COMBINATION; GENERATION; CHILDREN;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Dendritic cell vaccination is an experimental treatment for malignant gliomas, and has been subject of a translational program for more than ten years in our center. In vitro research, animal models and clinical trials for relapsed and newly diagnosed patients have been conducted. In this paper, we give an overview of the mechanism and rationale of this treatment for brain cancer. We also briefly discuss recently updated results of our clinical trials. Finally, we mention strategies to select patients for this therapy and additional immunotherapeutic strategies to further enhance the antitumor immune responses.

引用

页数：5

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