Acid-Catalyzed Synthesis of Bicyclo[3.n.1]alkenediones

被引：34
|
作者：
Michaelides, Iacovos N. [1 ]
Darses, Benjamin [1 ]
Dixon, Darren J. [1 ]
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 04期
基金：
英国工程与自然科学研究理事会;
关键词：
MULTIPLE-DRUG RESISTANCE; X-RAY-DIFFRACTION; STYRENYL SYSTEMS; BETA-KETOESTERS; NEOLIGNANS; DERIVATIVES; BURCHELLIN; ALKALOIDS; GUIANIN; ANALOGS;
D O I：
10.1021/ol102909t
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An acid-catalyzed Dieckmann-type reaction has been developed to access functionalized bicyclo[3.2.1]alkenediones. This methodology has been successfully extended to more substituted and larger ring homologues, providing a new and efficient route to the core of numerous attractive natural products and their analogues.
引用
收藏
页码：664 / 667
页数：4
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