Acid-Catalyzed Synthesis of Bicyclo[3.n.1]alkenediones

被引：34

作者：

Michaelides, Iacovos N. ^{[1
]}

Darses, Benjamin ^{[1
]}

Dixon, Darren J. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 04期

基金：

英国工程与自然科学研究理事会;

关键词：

MULTIPLE-DRUG RESISTANCE; X-RAY-DIFFRACTION; STYRENYL SYSTEMS; BETA-KETOESTERS; NEOLIGNANS; DERIVATIVES; BURCHELLIN; ALKALOIDS; GUIANIN; ANALOGS;

D O I：

10.1021/ol102909t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An acid-catalyzed Dieckmann-type reaction has been developed to access functionalized bicyclo[3.2.1]alkenediones. This methodology has been successfully extended to more substituted and larger ring homologues, providing a new and efficient route to the core of numerous attractive natural products and their analogues.

引用

页码：664 / 667

页数：4

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