Limitations in Clinical Translation of Nanoparticle-Based Gene Therapy

被引：13

作者：

Wong, Joanna K. L. ^{[1
]}

Mohseni, Rashin ^{[2
]}

Hamidieh, Amir Ali ^{[2
]}

MacLaren, Robert E. ^{[3
]}

Habib, Nagy ^{[4
]}

Seifalian, Alexander M. ^{[5
]}

机构：

[1] Imperial Coll London, Sch Med, London, England

[2] Univ Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran

[3] Univ Oxford, Dept Clin Neurosci, Nuffield Lab Ophthalmol, Oxford, England

[4] Imperial Coll London, Dept Surg & Canc, Fac Med, London, England

[5] Nanotechnol & Regenerat Med Ctr Ltd, London BioSci Innovat Ctr, London, England

来源：

TRENDS IN BIOTECHNOLOGY | 2017年 / 35卷 / 12期

关键词：

GRAPHENE; NANOMATERIALS; DELIVERY;

D O I：

10.1016/j.tibtech.2017.07.009

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Organic nanoparticle-based (ONP) gene therapy is a potential strategy to cure human cancer. However, there are still many practical barriers before the promising results from in vitro and preclinical studies can be translated to clinical success. We discuss the reasons behind the hesitant uptake by the clinic.

引用

页码：1124 / 1125

页数：3

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