New scaffolds for combinatorial synthesis. II. 6-sulfamoylquinolinecarboxylic acids

被引：26

作者：

Ivachtchenko, AV ^{[1
]}

Kobak, VV ^{[1
]}

Il'yin, AP ^{[1
]}

Trifilenkov, AS ^{[1
]}

Busel, AA ^{[1
]}

机构：

[1] Chem Divers Labs Inc, San Diego, CA 92121 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2003年 / 5卷 / 05期

关键词：

D O I：

10.1021/cc020090z

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Starting from 5-sulfamoylisatins, 6-sulfamoyl-4-quinolinecarboxylic acids and 2-methyl-6-sulfamoylquinoline-3,4-dicarboxylic acids were prepared by the Pfitzinger reaction. These acids and diacids were then converted to the corresponding amide and imide libraries. A patent based on these new combinatorial chemical libraries has been applied for. All the newly synthesized compounds are crystalline substances that were purified by recrystallization from suitable solvents and characterized primarily by H-1 NMR, C-13 NMR, and mass spectrometry.

引用

页码：645 / 652

页数：8

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