Short-term and low-dose IL-2 therapy restores the Th17/Treg balance in the peripheral blood of patients with primary Sjogren's syndrome

被引：97
|
作者：
Miao, Miao [1 ]
Hao, Zhenye [1 ]
Guo, Yingying [1 ]
Zhang, Xiaoying [2 ]
Zhang, Shengxiao [1 ]
Luo, Jing [2 ]
Zhao, Xiangcong [2 ]
Zhang, Chen [2 ]
Liu, Xiaoqing [1 ]
Wu, Xiaoyan [2 ]
Xu, Dan [1 ]
Zhao, Jinfang [3 ]
Lu, Xuechun [4 ]
Gao, Chong [5 ]
Li, Xiaofeng [2 ]
机构：
[1] Shanxi Med Univ, Hosp 2, Taiyuan, Shanxi, Peoples R China
[2] Shanxi Med Univ, Hosp 2, Dept Rheumatol, Taiyuan, Shanxi, Peoples R China
[3] Shanxi Med Univ, Dept Med Stat, Taiyuan, Shanxi, Peoples R China
[4] Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Hematol, Beijing, Peoples R China
[5] Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Boston, MA USA
来源：
ANNALS OF THE RHEUMATIC DISEASES | 2018年 / 77卷 / 12期
关键词：
T-CELLS; INTERLEUKIN-2;
D O I：
10.1136/annrheumdis-2018-213036
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：1838 / +
页数：3
相关论文
共 50 条
  • [1] Low Dose IL-2 Therapy Can Restore the Balance of Th17 and Treg Cells in Refractory Patients with Sjogren's Syndrome
    Miao, Miao
    Zhang, Shengxiao
    Liu, Xiao-Qing
    Wu, Xiaoyan
    Gao, Chong
    Li, Xiao-Feng
    [J]. ARTHRITIS & RHEUMATOLOGY, 2016, 68
  • [2] INFECTION AGGRAVATED DECREASE OF THE LEVEL OF TH17 AND TREG CELLS AND LOW-DOSE IL-2 REBALANCED TH17/TREG IN THE PERIPHERAL BLOOD OF PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHY
    Liang, Y.
    Wen, H. Y.
    Duan, Y.
    Liu, Y.
    Yu, Z.
    Niu, W.
    Gao, C.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 : 1587 - 1587
  • [3] Low dose of IL-2 combined with rapamycin restores and maintains the long-term balance of Th17/Treg cells in refractory SLE patients
    Chunmiao Zhao
    Yanfang Chu
    Zhaoyun Liang
    Bingying Zhang
    Xuxia Wang
    Xiaona Jing
    Meihua Hao
    Yiqi Wang
    Jia An
    Xingzhe Zhang
    Liguang Sun
    Junwei Chen
    [J]. BMC Immunology, 20
  • [4] Low dose of IL-2 combined with rapamycin restores and maintains the long-term balance of Th17/Treg cells in refractory SLE patients
    Zhao, Chunmiao
    Chu, Yanfang
    Liang, Zhaoyun
    Zhang, Bingying
    Wang, Xuxia
    Jing, Xiaona
    Hao, Meihua
    Wang, Yiqi
    An, Jia
    Zhang, Xingzhe
    Sun, Liguang
    Chen, Junwei
    [J]. BMC IMMUNOLOGY, 2019, 20 (01)
  • [5] LOW DOSE IL-2 THERAPY CAN RECOVERY TH17/TREG CELL BALANCE IN PATIENTS WITH ANKYLOSING SPONDYLITIS
    Xu, D.
    Fan, J.
    Chen, Q.
    Qin, K.
    Li, X.
    Gao, C.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 : 63 - 63
  • [6] Short-term and low-dose IL-2 therapy increases the reduced Treg cells in patients with microscopic polyangiitis
    Wu, Ruihe
    Mu, Yanfei
    Zhao, Xiangcong
    Zhao, Jinfang
    Gao, Chong
    Li, Xiaofeng
    Wang, Caihong
    [J]. AUTOIMMUNITY REVIEWS, 2022, 21 (09)
  • [7] Low-dose Interleukin-2 For Psoriasis Therapy Based on the Regulation of Th17/Treg Cell Balance in Peripheral Blood
    Zusha Qiao
    Wenpeng Zhao
    Yan Liu
    Wenli Feng
    Yan Ma
    Hongzhong Jin
    [J]. Inflammation, 2023, 46 : 2359 - 2373
  • [8] Low-dose Interleukin-2 For Psoriasis Therapy Based on the Regulation of Th17/Treg Cell Balance in Peripheral Blood
    Qiao, Zusha
    Zhao, Wenpeng
    Liu, Yan
    Feng, Wenli
    Ma, Yan
    Jin, Hongzhong
    [J]. INFLAMMATION, 2023, 46 (06) : 2359 - 2373
  • [9] Low-dose IL-2 alleviates drug-induced primary biliary cholangitis in mice by improving Treg and Th17 balance
    Wang, Zilong
    Feng, Bo
    Xie, Yandi
    Jin, Rui
    Liu, Zhicheng
    [J]. JOURNAL OF HEPATOLOGY, 2022, 77 : S26 - S27
  • [10] IL-2 Inhibition of Th17 Generation Rather Than Induction of Treg Cells Is Impaired in Primary Sjogren's Syndrome Patients
    Luo, Jing
    Ming, Bingxia
    Zhang, Cai
    Deng, Xiaofei
    Li, Pingfei
    Wei, Zhengping
    Xia, Yu
    Jiang, Kan
    Ye, Hong
    Ma, Wanli
    Liu, Zheng
    Li, Huabin
    Yang, Xiang-Ping
    Dong, Lingli
    [J]. FRONTIERS IN IMMUNOLOGY, 2018, 9
12345