Copper-catalyzed [3+2] cycloaddition reactions: synthesis of substituted pyrazolo[1,5-c] quinazolines with N-iminoquinazolinium ylides and olefins as starting materials

被引：7

作者：

Feng, Haiyan ^{[1
,2
,3
]}

Wang, Tao ^{[1
,2
,3
]}

Chen, Songtao ^{[3
]}

Huang, Yangfei ^{[3
]}

Yu, Weijie ^{[3
]}

Huang, Yuanyuan ^{[3
]}

Xiong, Fei ^{[1
,2
,3
]}

机构：

[1] Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China

[2] Jiangxi Normal Univ, Key Lab Chem Biol, Nanchang 330022, Jiangxi, Peoples R China

[3] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 98期

基金：

中国国家自然科学基金;

关键词：

GLY/NMDA RECEPTOR ANTAGONISTS; BIOLOGICAL EVALUATION; AZOMETHINE IMINES; DERIVATIVES; PYRAZOLO<1,5-C>QUINAZOLINES; HETEROCYCLES; SET;

D O I：

10.1039/c6ra22006a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we describe a copper-catalyzed [3 + 2] cycloaddition reaction between N-iminoquinazolinium ylide and various polar olefins in mild conditions. In this process, pyrazolo[1,5-c] quinazoline derivatives were efficiently synthesized via cycloaddition followed by oxo-dehydrogenation in moderate to good yield.

引用

页码：95774 / 95779

页数：6

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