[1] Toronto Hosp, Western Div, Toronto, ON M5T 2S8, Canada
[2] Univ Toronto, Glaxo Wellcome Sunnybrook Drug Safety Clin, Div Clin Pharmacol, Toronto, ON M4N 3M5, Canada
[3] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Pharm & Med, Toronto, ON, Canada
[4] Univ Toronto, Glaxo Wellcome Sunnybrook Drug Safety Clin, Div Dermatol, Toronto, ON M4N 3M5, Canada
[5] Sunnybrook Hlth Sci Ctr, Dept Med, Toronto, ON M4N 3M5, Canada
[6] Sunnybrook Hlth Sci Ctr, Dept Pharmacol, Toronto, ON M4N 3M5, Canada