Therapeutic potential of venom peptides

被引：599
|
作者：
Lewis, RJ [1 ]
Garcia, ML
机构：
[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia
[2] Xenome Ltd, Indooroopilly, Qld 4068, Australia
[3] Merck Res Labs, Dept Ion Channels, Rahway, NJ 07065 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2003年 / 2卷 / 10期
关键词：
D O I：
10.1038/nrd1197
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Venomous animals have evolved a vast array of peptide toxins for prey capture and defence. These peptides are directed against a wide variety of pharmacological targets, making them an invaluable source of ligands for studying the properties of these targets in different experimental paradigms. A number of these peptides have been used in vivo for proof-of-concept studies, with several having undergone preclinical or clinical development for the treatment of pain, diabetes, multiple sclerosis and cardiovascular diseases. Here we survey the pharmacology of venom peptides and assess their therapeutic prospects.
引用
下载
收藏
页码：790 / 802
页数：13
相关论文
共 50 条
  • [41] Therapeutic potential of marine peptides in malignant melanoma
    Ahmed, Salman
    Alam, Waqas
    Alsharif, Khalaf F.
    Aschner, Michael
    Alzahrani, Fuad M.
    Saso, Luciano
    Khan, Haroon
    ENVIRONMENTAL RESEARCH, 2023, 227
  • [42] Antimicrobial Peptides as Potential Therapeutic Agents: A Review
    Datta, Shreeja
    Roy, Arpita
    INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2021, 27 (01) : 555 - 577
  • [43] Snake Venom Peptides and Low Mass Proteins: Molecular Tools and Therapeutic Agents
    Almeida, J. R.
    Resende, L. M.
    Watanabe, R. K.
    Carregari, V. C.
    Huancahuire-Vega, S.
    Caldeira, C. A. da S.
    Coutinho-Neto, A.
    Soares, A. M.
    Vale, N.
    Gomes, P. A. de C.
    Marangoni, S.
    Calderon, L. de A.
    Da Silva, S. L.
    CURRENT MEDICINAL CHEMISTRY, 2017, 24 (30) : 3254 - 3282
  • [44] Activities of Venom Proteins and Peptides with Possible Therapeutic Applications from Bees and WASPS
    Ye, Xiujuan
    Guan, Suzhen
    Liu, Jiwen
    Ng, Charlene C. W.
    Chan, Gabriel H. H.
    Sze, Stephen C. W.
    Zhang, Kalin Y.
    Naude, Ryno
    Rolka, Krzysztof
    Wong, Jack Ho
    Ng, Tzi Bun
    PROTEIN AND PEPTIDE LETTERS, 2016, 23 (08): : 748 - 755
  • [45] Antitumoral Potential of Snake Venom Phospholipases A2 and Synthetic Peptides
    Sobrinho, Juliana C.
    Simoes-Silva, Rodrigo
    Holanda, Rudson J.
    Alfonso, Jorge
    Gomez, Ana F.
    Zanchi, Fernando B.
    Moreira-Dill, Leandro S.
    Grabner, Amy N.
    Zuliani, Juliana P.
    Calderon, Leonardo A.
    Soares, Andreimar M.
    CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2016, 17 (14) : 1201 - 1212
  • [46] Insulin Receptor Binding: From venom peptides to a potential diabetes treatment
    Jiracek, Jiri
    Zakova, Lenka
    ELIFE, 2019, 8
  • [47] Functional characteristic of snake venom disintegrins: Potential therapeutic implication
    Marcinkiewicz, C
    CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (07) : 815 - 827
  • [48] Therapeutic Use of Bee Venom and Potential Applications in Veterinary Medicine
    Bava, Roberto
    Castagna, Fabio
    Musella, Vincenzo
    Lupia, Carmine
    Palma, Ernesto
    Britti, Domenico
    VETERINARY SCIENCES, 2023, 10 (02)
  • [49] Therapeutic potential of snake venom in cancer therapy:current perspectives
    Vivek Kumar Vyas
    Keyur Brahmbhatt
    Hardik Bhatt
    Utsav Parmar
    Asian Pacific Journal of Tropical Biomedicine, 2013, (02) : 156 - 162
  • [50] Neuropharmacology of venom peptides
    Adams, David J.
    Lewis, Richard J.
    NEUROPHARMACOLOGY, 2017, 127 : 1 - 3
12345