Spontaneous regression of CIN and delayed-type hypersensitivity to HPV-16 oncoprotein E7

被引：68
|
作者：
Höpfl, R [1 ]
Heim, K
Christensen, N
Zumbach, K
Wieland, U
Volgger, B
Widschwendter, A
Haimbuchner, S
Müller-Holzner, E
Pawlita, M
Pfister, H
Fritsch, P
机构：
[1] Univ Innsbruck, Dept Dermatol & Venereol, A-6020 Innsbruck, Austria
[2] Univ Innsbruck, Dept Obstet, A-6020 Innsbruck, Austria
[3] Univ Innsbruck, Dept Gynaecol, A-6020 Innsbruck, Austria
[4] Univ Cologne, Inst Virol, D-5000 Cologne 41, Germany
[5] Penn State Univ, Milton S Hershey Med Ctr, Dept Pathol, Jake Gittien Canc Res Inst, Hershey, PA 17033 USA
[6] Deutsch Krebsforschungszentrum, D-6900 Heidelberg, Germany
来源：
LANCET | 2000年 / 356卷 / 9246期
关键词：
D O I：
10.1016/S0140-6736(00)03315-8
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We investigated delayed-type hypersensitivity to human papillomavirus (HPV) in women with cervical dysplasia or cancer, Women were challenged by skin tests with synthetic HPV-16 E7 oncoprotein peptides. 11 women were regressors (cleared disease without treatment) and 37 were progressors (required surgery). Antibodies to early antigens (markers for progression) were detectable in a higher proportion of cancer patients than all other patients, particularly progressors with cervical intraepithelial neoplasia (CIN). By contrast, cellular immunity to HPV-16 E7, measured by skin test. was significantly (p=0.0001) associated with clinical and cytological resolution of HPV-induced GIN, indicating that E7-specific T-helper cells have a role in control of HPV.
引用
收藏
页码：1985 / 1986
页数：2
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