Early intravenous lipid emulsion therapy for diphenhydramine overdose: a case report

被引：3
|
作者：
Clemons, Joseph [1 ]
Jandu, Arvinder [1 ]
Stein, Brandon [1 ]
Chary, Michael A. [2 ,3 ]
机构：
[1] Kendall Reg Med Ctr, Dept Emergency Med, Miami, FL USA
[2] Boston Childrens Hosp, Dept Med, Div Emergency Med, Boston, MA 02115 USA
[3] Weill Cornell Med Coll, Dept Emergency Med, Div Med Toxicol, New York, NY USA
来源：
TOXICOLOGY COMMUNICATIONS | 2021年 / 5卷 / 01期
关键词：
Intravenous lipid emulsion; toxicity; diphenhydramine; overdose; hypotension; resuscitation; INTRALIPID(R);
D O I：
10.1080/24734306.2020.1870078
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Diphenhydramine (DPH) is a lipophilic inverse agonist at the histamine receptor. Overdoses usually present with anticholinergic symptoms. Wide-complex tachycardia decompensating into cardiovascular collapse may occur in larger overdoses. Here we report a patient who developed ventricular dysrhythmias after ingestion of 83 mg/kg of diphenhydramine, went into cardiovascular collapse that was rescued with early administration of intravenous lipid emulsion.
引用
收藏
页码：15 / 18
页数：4
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