Overview of the safety of newer antiepileptic drugs

被引:41
|
作者
Shorvon, S [1 ]
Stefan, H [1 ]
机构
[1] UNIV ERLANGEN NURNBERG, NEUROL CLIN & POLYCLIN, D-8520 ERLANGEN, GERMANY
关键词
anticonvulsants; drug toxicity; lamotrigine; vigabatrin; gabapentin; tiagabine; felbamate; topiramate;
D O I
10.1111/j.1528-1157.1997.tb04519.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Standard antiepileptic drugs are associated with a wide variety of acute and chronic adverse events and with many interactions with each other and with non-AEDs that complicate patient management. The safety and interaction profiles of newer AEDs have also been intensively studied. Safety data are available for six of the newer AEDs, lamotrigine (LTG), vigabatrin (VGB), gabapentin (GBP), tiagabine (TGB), felbamate (FBM), and topiramate (TPM). The potential for the most recently developed AEDs for producing rare idiosyncratic reactions cannot be ascertained until additional patient exposures have been reported from careful postmarking surveillance.
引用
收藏
页码:S45 / S51
页数:7
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