TRPM2 activation: Paradigm shifted?

被引：8
|
作者：
Fliegert, Ralf [1 ]
Hoelzer, Hans T. [1 ]
Guse, Andreas H. [1 ]
机构：
[1] Univ Med Ctr Hamburg Eppendorf, Dept Biochem & Mol Cell Biol, Calcium Signaling Grp, Martinistr 52, D-20246 Hamburg, Germany
来源：
CELL CALCIUM | 2018年 / 76卷
关键词：
TRP channel; Ion channel structure; ADPR; Calcium; ADP-RIBOSE; CHANNEL; DOMAIN;
D O I：
10.1016/j.ceca.2018.11.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Transient receptor potential cation channel, subtype melastatin 2 (TRPM2), is important for several physiological functions, such as immune response or temperature regulation. Recently, the structure of full-length TRPM2 from zebrafish was published (Huang et al., 2018) proposing a new activation mechanism - is it really a paradigm shift or just reflects evolution of the channel?.
引用
收藏
页码：132 / 134
页数：3
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