TRPM2 activation: Paradigm shifted?

被引：8
|
作者：
Fliegert, Ralf [1 ]
Hoelzer, Hans T. [1 ]
Guse, Andreas H. [1 ]
机构：
[1] Univ Med Ctr Hamburg Eppendorf, Dept Biochem & Mol Cell Biol, Calcium Signaling Grp, Martinistr 52, D-20246 Hamburg, Germany
来源：
CELL CALCIUM | 2018年 / 76卷
关键词：
TRP channel; Ion channel structure; ADPR; Calcium; ADP-RIBOSE; CHANNEL; DOMAIN;
D O I：
10.1016/j.ceca.2018.11.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Transient receptor potential cation channel, subtype melastatin 2 (TRPM2), is important for several physiological functions, such as immune response or temperature regulation. Recently, the structure of full-length TRPM2 from zebrafish was published (Huang et al., 2018) proposing a new activation mechanism - is it really a paradigm shift or just reflects evolution of the channel?.
引用
收藏
页码：132 / 134
页数：3
相关论文
共 50 条
  • [1] Pathophysiological role of TRPM2 channel in microglial activation
    Miyake, Takahito
    Shirakawa, Hisashi
    Kusano, Ayaka
    Sakimoto, Shinya
    Konno, Masakazu
    Nakagawa, Takayuki
    Kaneko, Shuji
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, 118 : 136P - 136P
  • [2] TRPM2 in Cancer
    Miller, Barbara A.
    CELL CALCIUM, 2019, 80 : 8 - 17
  • [3] Involvement of TRPM2 channel in mechanisms underlying microglial activation
    Shirakawa, Hisashi
    Kusano, Ayaka
    Miyake, Takahito
    Konno, Masakazu
    Nakagawa, Takayuki
    Kaneko, Shuji
    NEUROSCIENCE RESEARCH, 2011, 71 : E221 - E222
  • [4] Curcumin inhibits activation of TRPM2 channels in rat hepatocytes
    Kheradpezhouh, E.
    Barritt, G. J.
    Rychkov, G. Y.
    REDOX BIOLOGY, 2016, 7 : 1 - 7
  • [5] Lys1110 of TRPM2 is critical for channel activation
    Kim, Taek-Keun
    Nam, Joo Hyun
    Ahn, Won-Gyun
    Kim, Nam-Ho
    Ham, Hwa-Yong
    Hong, Chang-Won
    Nam, Ju-Suk
    Lee, Jongho
    Huh, Sung-Oh
    So, Insuk
    Kim, Sung Joon
    Song, Dong-Keun
    BIOCHEMICAL JOURNAL, 2013, 455 : 319 - 327
  • [6] Heat-evoked activation of ion channel, TRPM2
    Togashi, K
    Hara, Y
    Higashi, T
    Konishi, Y
    Tominaga, T
    Mori, Y
    Tominaga, M
    FASEB JOURNAL, 2005, 19 (05): : A1164 - A1164
  • [7] Calcium dependence of human TRPM2 cation channel activation
    McHugh, D
    Flemming, R
    Xu, SZ
    Scharenberg, AM
    Beech, DJ
    JOURNAL OF PHYSIOLOGY-LONDON, 2002, 544 : 6P - 7P
  • [8] TRPM2 Is Not Required for T-Cell Activation and Differentiation
    Lory, Niels C.
    Nawrocki, Mikolaj
    Corazza, Martina
    Schmid, Joanna
    Schumacher, Valea
    Bedke, Tanja
    Menzel, Stephan
    Koch-Nolte, Friedrich
    Guse, Andreas H.
    Huber, Samuel
    Mittruecker, Hans-Willi
    FRONTIERS IN IMMUNOLOGY, 2022, 12
  • [9] TRPM2 and warmth sensation
    Chun-Hsiang Tan
    Peter A. McNaughton
    Pflügers Archiv - European Journal of Physiology, 2018, 470 : 787 - 798
  • [10] Warm feelings for TRPM2
    Voets, Thomas
    CELL RESEARCH, 2016, 26 (11) : 1174 - 1175
12345