High-performance liquid chromatographic method for the determination of nimesulide in pharmaceutical preparations

被引：21
|
作者：
Nagaralli, BS [1 ]
Seetharamappa, J [1 ]
Gowda, BG [1 ]
Melwanki, MB [1 ]
机构：
[1] Karnatak Univ, Dept Chem, Dharwad 580003, Karnataka, India
来源：
JOURNAL OF ANALYTICAL CHEMISTRY | 2003年 / 58卷 / 08期
关键词：
Analytical Chemistry; Acetonitrile; Liquid Chromatographic; Mobile Phase; Ibuprofen;
D O I：
10.1023/A:1025095829622
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple, rapid, and precise high-performance liquid chromatographic method for the determination of nimesulide in pharmaceutical preparations was proposed using Ibuprofen as an internal standard. The separation was performed on a CLC C-18 (5 mum, 25 cm x 4.6 mm i.d.) column with a mobile phase consisting of an acetonitrile-0.05 M KH2PO4 buffer mixture of pH 7.00 (55 : 45, v/v). The detection was carried out at 230 nm and the linearity range was found to be 0.5-100 mug/mL. The method has been applied successfully to the determination of nimesulide in pharmaceutical formulations. The recovery values were found to be in the range of 99.23-100.13% with RSD values of less than 0.97%.
引用
收藏
页码：778 / 780
页数：3
相关论文
共 50 条
  • [21] High-performance thin-layer chromatographic determination of idebenone in pharmaceutical preparations
    Sane, R.T.
    Francis, Mary
    Khatri, Aamer
    Devarajan, Sayini
    Journal of Planar Chromatography - Modern TLC, 2001, 14 (06): : 445 - 448
  • [22] High-Performance Thin-Layer Chromatographic Determination of Idebenone in Pharmaceutical Preparations
    R. T. Sane
    Mary Francis
    Aamer Khatri
    Sayini Devarajan
    JPC – Journal of Planar Chromatography – Modern TLC, 2001, 14 : 445 - 448
  • [23] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF COMPONENTS OF BLEOMYCIN PREPARATIONS
    ASZALOS, A
    CRAWFORD, J
    VOLLMER, P
    KANTOR, N
    ALEXANDER, T
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1981, 70 (08) : 878 - 880
  • [24] DETERMINATION OF HEPTAMINOL IN PHARMACEUTICAL PREPARATIONS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    NICOLAS, A
    LEROY, P
    MOREAU, A
    MIRJOLET, M
    JOURNAL OF CHROMATOGRAPHY, 1982, 244 (01): : 148 - 152
  • [25] HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR THE QUANTITATIVE ANALYSIS OF CEFUROXIME IN PHARMACEUTICAL PREPARATIONS
    Siddiqui, Masoom Raza
    Alothman, Zeid A.
    Wabaidur, Saikh Mohammad
    Khan, Moonis Ali
    Alam, Md. Sarfaraz
    Ali, Md. Sajid
    JOURNAL OF THE CHILEAN CHEMICAL SOCIETY, 2015, 60 (02): : 2869 - 2871
  • [26] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF CLOXACILLIN IN COMMERCIAL PREPARATIONS AND FOR STABILITY STUDIES
    HSU, MC
    CHENG, MC
    JOURNAL OF CHROMATOGRAPHY, 1991, 549 (1-2): : 410 - 415
  • [27] A high-performance liquid chromatographic method for the determination of monofluoroacetate
    Minnaar, PP
    Swan, GE
    McCrindle, RI
    de Beer, WHJ
    Naudé, TW
    JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2000, 38 (01) : 16 - 20
  • [28] A Stability-Indicating High-Performance Liquid Chromatographic Method for the Determination of Methocarbamol in Veterinary Preparations
    Rosasco, Maria A.
    Ceresole, Rita
    Forastieri, Clara C.
    Segall, Adriana I.
    JOURNAL OF AOAC INTERNATIONAL, 2009, 92 (05) : 1602 - 1605
  • [29] A stability-indicating high-performance liquid chromatographic method for the determination of methocarbamol in veterinary preparations
    Rosasco, María A.
    Ceresole, Rita
    Forastieri, Clara C.
    Segall, Adriana I.
    Journal of AOAC International, 2009, 92 (05): : 1602 - 1605
  • [30] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF TIOCONAZOLE IN PHARMACEUTICAL FORMULATIONS
    BERRIDGE, JC
    LAST, PE
    PLATT, RV
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1985, 3 (04) : 391 - 394
12345