High-performance liquid chromatographic method for the determination of nimesulide in pharmaceutical preparations

被引：21
|
作者：
Nagaralli, BS [1 ]
Seetharamappa, J [1 ]
Gowda, BG [1 ]
Melwanki, MB [1 ]
机构：
[1] Karnatak Univ, Dept Chem, Dharwad 580003, Karnataka, India
来源：
JOURNAL OF ANALYTICAL CHEMISTRY | 2003年 / 58卷 / 08期
关键词：
Analytical Chemistry; Acetonitrile; Liquid Chromatographic; Mobile Phase; Ibuprofen;
D O I：
10.1023/A:1025095829622
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple, rapid, and precise high-performance liquid chromatographic method for the determination of nimesulide in pharmaceutical preparations was proposed using Ibuprofen as an internal standard. The separation was performed on a CLC C-18 (5 mum, 25 cm x 4.6 mm i.d.) column with a mobile phase consisting of an acetonitrile-0.05 M KH2PO4 buffer mixture of pH 7.00 (55 : 45, v/v). The detection was carried out at 230 nm and the linearity range was found to be 0.5-100 mug/mL. The method has been applied successfully to the determination of nimesulide in pharmaceutical formulations. The recovery values were found to be in the range of 99.23-100.13% with RSD values of less than 0.97%.
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页码：778 / 780
页数：3
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