Tumor-infiltrating lymphocytes as a feasible adjuvant immunotherapy for osteosarcoma with a poor response to neoadjuvant chemotherapy

被引：17
|
作者：
Shi, Jing [1 ]
Li, Ming [1 ]
Yang, Rongzhi [1 ]
机构：
[1] Zhengzhou Univ, Dept Orthoped Surg, Luoyang Cent Hosp, Luoyang 471009, Peoples R China
来源：
IMMUNOTHERAPY | 2020年 / 12卷 / 09期
关键词：
adjuvant chemotherapy; adverse effects; immunotherapy; osteosarcoma; PD1; phenotype; poor response; prognostic factor; retrospective; TILs; SOUTHWEST-ONCOLOGY-GROUP; HIGH-GRADE OSTEOSARCOMA; METASTATIC MELANOMA; T-CELLS; NONMETASTATIC OSTEOSARCOMA; PROGNOSTIC-FACTORS; EWINGS-SARCOMA; OSTEO-SARCOMA; PHASE-II; CANCER;
D O I：
10.2217/imt-2020-0107
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Aim: To investigate the efficacy of adjuvant chemotherapy plus tumor-infiltrating lymphocytes (TILs) therapy in osteosarcoma patients with a poor response to neoadjuvant chemotherapy. Materials & methods: 40 patients received adjuvant chemotherapy (Group 1) and 40 patients received adjuvant chemotherapy plus TILs therapy (Group 2). Disease-free survival (DFS) and overall survival (OS) were analyzed by Kaplan-Meier analysis. Results: The median DFS (mDFS; 65.3 months) and median OS (mOS; 95.8 months) in Group 2 were significantly prolonged compared with those in Group 1 (55.5 months for mDFS and 80.4 months for mOS). Univariate and multivariate analyses indicated that a greater number of TILs transfused was an independent prognostic factor for both mDFS and mOS. Conclusion: Adjuvant chemotherapy plus TILs therapy may prolong survival of patients with a poor response to neoadjuvant chemotherapy.
引用
收藏
页码：641 / 652
页数：12
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