Striking a Balance Between Feasible and Realistic Biological Models

被引：2

作者：

Califano, Andrea ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Columbia Univ, Columbia Initiat Syst Biol, New York, NY 10032 USA

[2] Columbia Univ, Ctr Computat Biol & Bioinformat, New York, NY 10032 USA

[3] Columbia Univ, Dept Biomed Informat, New York, NY 10032 USA

[4] Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA

[5] Columbia Univ, Inst Canc Genet, New York, NY 10032 USA

[6] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2011年 / 3卷 / 103期

关键词：

TUMOR-REGRESSION; MYC INACTIVATION; CANCER; ONCOGENE; CELLS; PROLIFERATION; ADDICTION; THERAPY; GROWTH; BRAIN;

D O I：

10.1126/scitranslmed.3003079

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The fusion of empirical science with large-scale computing platforms has allowed rapid advances in our ability to model physiological and pathophysiological processes in silico. In this week's issue of Science Translational Medicine, Tran et al. present a simple framework for the quantitative modeling of oncogene addiction that provides mechanistic insights into tumor biology.

引用

页数：3

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