Immune-based therapies for hepatocellular carcinoma

被引：181

作者：

Pinato, David J. ^{[1
]}

Guerra, Nadia ^{[2
]}

Fessas, Petros ^{[1
]}

Murphy, Ravindhi ^{[1
]}

Mineo, Takashi ^{[3
]}

Mauri, Francesco A. ^{[1
]}

Mukherjee, Sujit K. ^{[4
]}

Thursz, Mark ^{[4
]}

Wong, Ching Ngar ^{[1
]}

Sharma, Rohini ^{[1
]}

Rimassa, Lorenza ^{[5
,6
]}

机构：

[1] Imperial Coll London, Hammersmith Hosp, Dept Surg & Canc, Du Cane Rd, London W12 0HS, England

[2] Imperial Coll London, Dept Life Sci, South Kensington Campus,Exhibit Rd, London SW7 2AZ, England

[3] Tokyo Med & Dent Univ, Tokyo, Japan

[4] Imperial Coll London, Dept Metab Digest & Reprod, St Marys Hosp, Praed St, London, England

[5] Humanitas Clin & Res Ctr IRCCS, Med Oncol & Haematol Unit, Humanitas Canc Ctr, Via Manzoni 56, I-20089 Milan, Italy

[6] Humanitas Univ, Dept Biomed Sci, Via Rita Levi Montalcini, I-20090 Milan, Italy

来源：

ONCOGENE | 2020年 / 39卷 / 18期

基金：

英国惠康基金;

关键词：

REGULATORY T-CELLS; GROWTH-FACTOR-BETA; CHRONIC HEPATITIS-B; SUPPRESSOR-CELLS; DENDRITIC CELLS; TUMOR MICROENVIRONMENT; DOUBLE-BLIND; PHASE-III; TGF-BETA; ADOPTIVE IMMUNOTHERAPY;

D O I：

10.1038/s41388-020-1249-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related death. The immune-rich contexture of the HCC microenvironment makes this tumour an appealing target for immune-based therapies. Here, we discuss how the functional characteristics of the liver microenvironment can potentially be harnessed for the treatment of HCC. We will review the evidence supporting a therapeutic role for vaccines, cell-based therapies and immune-checkpoint inhibitors and discuss the potential for patient stratification in an attempt to overcome the series of failures that has characterised drug development in this disease area.

引用

页码：3620 / 3637

页数：18

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