Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans

被引：40

作者：

Hong, H

Gates, PJ

Staunton, J

Stinear, T

Cole, ST

Leadlay, PF

Spencer, JB

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

[3] Inst Pasteur, Unite Genet Mol Bacterienne, F-75015 Paris, France

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 22期

关键词：

D O I：

10.1039/b308163j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

LC-MSn analysis of mycolactone toxin from extracts of Mycobacterium ulcerans has shown that minor co-metabolites, including two previously unreported, differ structurally from mycolactone only in a small portion of the polyketide side-chain.

引用

页码：2822 / 2823

页数：2

共 3 条

[1] A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase
Hong, H
Spencer, JB
Porter, JL
Leadlay, PF
Stinear, T
[J]. CHEMBIOCHEM, 2005, 6 (04) : 643 - 648
[2] Separation and identification of cholesterol metabolites in rat brain using LC-MSn
Griffiths, W. J.
Milton, D.
[J]. LC GC EUROPE, 2007, : 26 - 26
[3] Identification of rat urinary metabolites of rifabutin using LC-MSn and LC-HR-MS
Prasad, Bhagwat
Singh, Saranjit
[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 41 (01) : 173 - 188

← 1 →