A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase

被引：45

作者：

Hong, H

Spencer, JB

Porter, JL

Leadlay, PF

Stinear, T

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[3] Monash Univ, Dept Microbiol, Clayton, Vic 3800, Australia

来源：

CHEMBIOCHEM | 2005年 / 6卷 / 04期

关键词：

biosynthesis; buruli ulcer; Mycobacterium; mycolactone; polyketides;

D O I：

10.1002/cbic.200400339

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New analogues of the toxin mycolactone have been identified in a pathogenic Chinese strain of Mycobacterium ulcerans. They possess an extra methyl group at C2′ (shown in red) compared to mycolactone A as a result of the recruitment of a single catalytic domain of altered specificity in the mycolactone polyketide synthase. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：643 / 648

页数：6