Neuronal regulation of alternative pre-mRNA splicing

被引：285
|
作者：
Li, Qin
Lee, Ji-Ann
Black, Douglas L.
机构：
[1] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA
来源：
NATURE REVIEWS NEUROSCIENCE | 2007年 / 8卷 / 11期
关键词：
D O I：
10.1038/nrn2237
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alternative pre-mRNA splicing has an important role in the control of neuronal gene expression. Many neuronal proteins are structurally diversified through the differential inclusion and exclusion of sequences in the final spliced mRNA. Here, we discuss common mechanisms of splicing regulation and provide examples of how alternative splicing has important roles in neuronal development and mature neuron function. Finally, we describe regulatory proteins that control the splicing of some neuronally expressed transcripts.
引用
收藏
页码：819 / 831
页数：13
相关论文
共 50 条
  • [41] The role of alternative pre-mRNA splicing in cancer progression
    Choi, Sunkyung
    Cho, Namjoon
    Kim, Eun-Mi
    Kim, Kee K.
    CANCER CELL INTERNATIONAL, 2023, 23 (01)
  • [42] Alternative pre-mRNA splicing and proteome expansion in metazoans
    Tom Maniatis
    Bosiljka Tasic
    Nature, 2002, 418 : 236 - 243
  • [43] Single molecule profiling of alternative pre-mRNA splicing
    Zhu, J
    Shendure, J
    Mitra, RD
    Church, GM
    SCIENCE, 2003, 301 (5634) : 836 - 838
  • [44] Role of alternative pre-mRNA splicing in temperature signaling
    Capovilla, Giovanna
    Pajoro, Alice
    Immink, Richard G. H.
    Schmid, Markus
    CURRENT OPINION IN PLANT BIOLOGY, 2015, 27 : 97 - 103
  • [45] Modulation of alternative pre-mRNA splicing in vivo by pinin
    Wang, P
    Lou, PJ
    Leu, S
    Ouyang, P
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 294 (02) : 448 - 455
  • [46] Alternative pre-mRNA splicing in digestive tract malignancy
    Miura, Koh
    Ohnuma, Shinobu
    Fujibuchi, Wataru
    Ishida, Kazuyuki
    Sasaki, Iwao
    CANCER RESEARCH, 2012, 72
  • [47] Tailoring of Membrane Proteins by Alternative Splicing of Pre-mRNA
    Mittendorf, Kathleen F.
    Deatherage, Catherine L.
    Ohi, Melanie D.
    Sanders, Charles R.
    BIOCHEMISTRY, 2012, 51 (28) : 5541 - 5556
  • [48] Blood coagulation and alternative pre-mRNA splicing: An overview
    Bogdanov, Vladimir Y.
    CURRENT MOLECULAR MEDICINE, 2006, 6 (08) : 859 - 869
  • [49] Alternative pre-mRNA splicing:: the logic of combinatorial control
    Smith, CWJ
    Valcárcel, J
    TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (08) : 381 - 388
  • [50] Donor site competition is involved in the regulation of alternative splicing of the rat β-tropomyosin pre-mRNA
    Chen, CD
    Helfman, DM
    RNA, 1999, 5 (02) : 290 - 301
12345